InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PTPRA

Summary

InnateDB Gene

IDBG-44167.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRA

Gene Name

protein tyrosine phosphatase, receptor type, A

Synonyms

HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA; PTPRL2; R-PTP-alpha; RPTPA

Species

Homo sapiens

Ensembl Gene

ENSG00000132670

Encoded Proteins

IDBP-44179

protein tyrosine phosphatase, receptor type, A

IDBP-44181

protein tyrosine phosphatase, receptor type, A

IDBP-44183

protein tyrosine phosphatase, receptor type, A

IDBP-44187

protein tyrosine phosphatase, receptor type, A

IDBP-229432

protein tyrosine phosphatase, receptor type, A

IDBP-363326

protein tyrosine phosphatase, receptor type, A

IDBP-363339

protein tyrosine phosphatase, receptor type, A

IDBP-363350

protein tyrosine phosphatase, receptor type, A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:2864184-3039076

Strand

Forward strand

Band

p13

Transcripts

ENST00000380393	ENSP00000369756
ENST00000356147	ENSP00000348468
ENST00000216877	ENSP00000216877
ENST00000318266	ENSP00000314568
ENST00000399903	ENSP00000382787
ENST00000455631	ENSP00000414089
ENST00000431048	ENSP00000390775
ENST00000430705	ENSP00000394132

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006470	protein dephosphorylation
GO:0007411	axon guidance
GO:0008286	insulin receptor signaling pathway
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027303

View Gene Order

ENSBTAG00000011425

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

NetPath_11

TCR pathway

REACTOME

REACT_18334

NCAM signaling for neurite out-growth pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

integrin_a4b1_pathway

Alpha4 beta1 integrin signaling events

insulin_pathway

Insulin Pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.269577 Hs.737679

RefSeq

NM_002836 NM_080840 NM_080841

HUGO

OMIM

CCDS

CCDS13038 CCDS13039

HPRD

01476

IMGT

EMBL

GenPept

RNA Seq Atlas