InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PTPRA

Summary

InnateDB Gene

IDBG-640142.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRA

Gene Name

receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011425

Encoded Proteins

IDBP-692439

protein tyrosine phosphatase, receptor type, A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132670:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:52600919-52771800

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015189

ENSBTAP00000015189

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006470	protein dephosphorylation
GO:0008286	insulin receptor signaling pathway
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation