Version 5.4
Homo sapiens Gene: DNAAF1
Summary
InnateDB Gene IDBG-44266.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAAF1
Gene Name dynein, axonemal, assembly factor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154099
Encoded Proteins
IDBP-44268
dynein, axonemal, assembly factor 1
IDBP-750869
IDBP-752545
IDBP-753528
IDBP-746608
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is cilium-specific and is required for the stability of the ciliary architecture. It is involved in the regulation of microtubule-based cilia and actin-based brush border microvilli. Mutations in this gene are associated with primary ciliary dyskinesia-13.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:84145287-84178767
Strand Forward strand
Band q24.1
Transcripts
ENST00000378553 ENSP00000367815
ENST00000562024
ENST00000569735 ENSP00000454960
ENST00000567666
ENST00000564928 ENSP00000457899
ENST00000570298
ENST00000563093 ENSP00000457373
ENST00000563818
ENST00000567918 ENSP00000455154
ENST00000623406
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0045502 dynein binding
Biological Process
GO:0001947 heart looping
GO:0003341 cilium movement
GO:0003356 regulation of cilium beat frequency
GO:0030324 lung development
GO:0035469 determination of pancreatic left/right asymmetry
GO:0036158 outer dynein arm assembly
GO:0036159 inner dynein arm assembly
GO:0044458 motile cilium assembly
GO:0060271 cilium morphogenesis
GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry
GO:0060972 left/right pattern formation
GO:0070286 axonemal dynein complex assembly
GO:0071907 determination of digestive tract left/right asymmetry
GO:0071910 determination of liver left/right asymmetry
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005930 axoneme
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031831
View Gene Order
ENSBTAG00000018771
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.310164 Hs.703315
RefSeq NM_178452 XM_006721129
HUGO
OMIM
CCDS CCDS10943
HPRD 14023
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca