InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: USP10

Summary

InnateDB Gene

IDBG-44807.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP10

Gene Name

ubiquitin specific peptidase 10

Synonyms

UBPO

Species

Homo sapiens

Ensembl Gene

ENSG00000103194

Encoded Proteins

IDBP-44811

ubiquitin specific peptidase 10

IDBP-600322

ubiquitin specific peptidase 10

IDBP-751102

IDBP-749470

IDBP-752093

IDBP-748302

IDBP-754143

IDBP-751378

IDBP-753425

IDBP-750370

IDBP-750240

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:84699978-84779922

Strand

Forward strand

Band

q24.1

Transcripts

ENST00000219473	ENSP00000219473
ENST00000540269	ENSP00000445589
ENST00000570053	ENSP00000454751
ENST00000569038	ENSP00000462762
ENST00000562283	ENSP00000455712
ENST00000569925	ENSP00000454987
ENST00000566378
ENST00000563433
ENST00000570191	ENSP00000457411
ENST00000564566
ENST00000563048	ENSP00000454902
ENST00000562092
ENST00000562743
ENST00000566512
ENST00000563892	ENSP00000458089
ENST00000569511
ENST00000563023
ENST00000563386	ENSP00000454943
ENST00000567526	ENSP00000455865

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.

Experimentally validated
Total	46 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0044325	ion channel binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006281	DNA repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006914	autophagy
GO:0010506	regulation of autophagy
GO:0016579	protein deubiquitination
GO:0030330	DNA damage response, signal transduction by p53 class mediator

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0045111	intermediate filament cytoskeleton

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031826

View Gene Order

ENSBTAG00000009446

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.136778 Hs.449100 Hs.594990

RefSeq

NM_001272075 NM_005153 XM_006721332

HUGO

OMIM

CCDS

CCDS45537 CCDS62004

HPRD

07029

IMGT

EMBL

GenPept

RNA Seq Atlas