Version 5.4
Homo sapiens Gene: ROBO2
Summary
InnateDB Gene IDBG-45400.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ROBO2
Gene Name roundabout, axon guidance receptor, homolog 2 (Drosophila)
Synonyms SAX3
Species Homo sapiens
Ensembl Gene ENSG00000185008
Encoded Proteins
IDBP-45402
roundabout, axon guidance receptor, homolog 2 (Drosophila)
IDBP-476410
roundabout, axon guidance receptor, homolog 2 (Drosophila)
IDBP-484811
roundabout, axon guidance receptor, homolog 2 (Drosophila)
IDBP-484584
roundabout, axon guidance receptor, homolog 2 (Drosophila)
IDBP-484824
roundabout, axon guidance receptor, homolog 2 (Drosophila)
IDBP-476790
roundabout, axon guidance receptor, homolog 2 (Drosophila)
IDBP-474518
roundabout, axon guidance receptor, homolog 2 (Drosophila)
IDBP-483789
roundabout, axon guidance receptor, homolog 2 (Drosophila)
IDBP-809126
roundabout, axon guidance receptor, homolog 2 (Drosophila)
IDBP-809154
roundabout, axon guidance receptor, homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. The encoded protein is a receptor for SLIT2, molecules known to function in axon guidance and cell migration. Defects in this gene are the cause of vesicoureteral reflux type 2. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:75906695-77649964
Strand Forward strand
Band p12.3
Transcripts
ENST00000332191 ENSP00000327536
ENST00000487694 ENSP00000417335
ENST00000475034
ENST00000461745 ENSP00000417164
ENST00000473767 ENSP00000418117
ENST00000490991 ENSP00000418344
ENST00000471893 ENSP00000418190
ENST00000469233
ENST00000475334 ENSP00000418446
ENST00000470802
ENST00000490534 ENSP00000417471
ENST00000602589 ENSP00000473268
ENST00000614793 ENSP00000480344
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008046 axon guidance receptor activity
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0007420 brain development
GO:0016199 axon midline choice point recognition
GO:0021510 spinal cord development
GO:0021891 olfactory bulb interneuron development
GO:0031290 retinal ganglion cell axon guidance
GO:0032870 cellular response to hormone stimulus
GO:0050772 positive regulation of axonogenesis
GO:0050925 negative regulation of negative chemotaxis
GO:0051964 negative regulation of synapse assembly
GO:0061364 apoptotic process involved in luteolysis
Cellular Component
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030673 axolemma
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052516
View Gene Order
ENSBTAG00000010462
Not yet available
Pathways
NETPATH
REACTOME
REACT_19376
Regulation of Commissural axon pathfinding by Slit and Robo pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.13305 Hs.713996
RefSeq NM_001128929 NM_001290039 NM_001290040 NM_002942 XM_006713279
HUGO
OMIM
CCDS CCDS43109 CCDS54609
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca