InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ROBO2

Summary

InnateDB Gene

IDBG-630577.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ROBO2

Gene Name

Uncharacterized protein

Synonyms

ROBO2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010462

Encoded Proteins

IDBP-682114

roundabout, axon guidance receptor, homolog 2 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185008:
This gene belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. The encoded protein is a receptor for SLIT2, molecules known to function in axon guidance and cell migration. Defects in this gene are the cause of vesicoureteral reflux type 2. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:24395321-24588683

Strand

Forward strand

Band

Transcripts

ENSBTAT00000048830

ENSBTAP00000045807

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0007156	homophilic cell adhesion
GO:0007411	axon guidance
GO:0007420	brain development
GO:0032870	cellular response to hormone stimulus
GO:0050772	positive regulation of axonogenesis
GO:0050925	negative regulation of negative chemotaxis
GO:0061364	apoptotic process involved in luteolysis

Cellular Component

GO:0009986	cell surface
GO:0030673	axolemma
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000185008

View Gene Order

ENSMUSG00000052516

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19376

Regulation of Commissural axon pathfinding by Slit and Robo pathway

REACT_19351

Signaling by Robo receptor pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04360

Axon guidance pathway

mmu04360

Axon guidance pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.110263

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas