InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Robo2

Summary

InnateDB Gene

IDBG-171179.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Robo2

Gene Name

roundabout homolog 2 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052516

Encoded Proteins

IDBP-273761

roundabout homolog 2 (Drosophila)

IDBP-400965

roundabout homolog 2 (Drosophila)

IDBP-400963

roundabout homolog 2 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185008:
This gene belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. The encoded protein is a receptor for SLIT2, molecules known to function in axon guidance and cell migration. Defects in this gene are the cause of vesicoureteral reflux type 2. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:73892306-74411825

Strand

Reverse strand

Band

C3.1

Transcripts

ENSMUST00000116586	ENSMUSP00000112285
ENSMUST00000117785	ENSMUSP00000112776
ENSMUST00000117200	ENSMUSP00000113795
ENSMUST00000149114
ENSMUST00000137420
ENSMUST00000138852
ENSMUST00000147408
ENSMUST00000140062
ENSMUST00000156010

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008046	axon guidance receptor activity
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0007156	homophilic cell adhesion
GO:0007411	axon guidance
GO:0007420	brain development
GO:0021510	spinal cord development
GO:0032870	cellular response to hormone stimulus
GO:0050772	positive regulation of axonogenesis
GO:0050925	negative regulation of negative chemotaxis
GO:0061364	apoptotic process involved in luteolysis

Cellular Component

GO:0009986	cell surface
GO:0030673	axolemma
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000185008

View Gene Order

ENSBTAG00000010462

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04360

Axon guidance pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19376

Regulation of Commissural axon pathfinding by Slit and Robo pathway

REACT_19351

Signaling by Robo receptor pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04360

Axon guidance pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.171736 Mm.410124 Mm.437237

RefSeq

NM_175549 XM_006523041 XM_006523042 XM_006523043 XM_006523044 XM_006523049

OMIM

CCDS

CCDS49886

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas