Version 5.4
Homo sapiens Gene: EPHA1
Summary
InnateDB Gene IDBG-46224.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPHA1
Gene Name EPH receptor A1
Synonyms EPH; EPHT; EPHT1
Species Homo sapiens
Ensembl Gene ENSG00000146904
Encoded Proteins
IDBP-46226
EPH receptor A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:143390289-143408892
Strand Reverse strand
Band q35
Transcripts
ENST00000275815 ENSP00000275815
ENST00000458129
ENST00000488068
ENST00000465208
ENST00000494989
ENST00000479459
ENST00000497891
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
Biological Process
GO:0001525 angiogenesis
GO:0001954 positive regulation of cell-matrix adhesion
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0032314 regulation of Rac GTPase activity
GO:0032862 activation of Rho GTPase activity
GO:0034446 substrate adhesion-dependent cell spreading
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0051496 positive regulation of stress fiber assembly
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029859
View Gene Order
ENSBTAG00000006359
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_111045
Developmental Biology pathway
REACT_200812
Transcriptional regulation of pluripotent stem cells pathway
REACT_200759
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway
REACT_18266
Axon guidance pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt P21709
TrEMBL
UniProt Splice Variant
Entrez Gene 2041
UniGene
RefSeq NM_005232
HUGO HGNC:3385
OMIM 179610
CCDS CCDS5884
HPRD
IMGT
EMBL AC092214 AF101165 AF101166 AF101167 AF101168 AF101169 AF101170 AF101171 BC130291 CH236959 CH471198 M18391 Z27409
GenPept AAA36747 AAD43440 AAI30292 AAS07458 CAA81796 EAL23789 EAW51846 EAW51847
RNA Seq Atlas 2041

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca