InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EPHA1

Summary

InnateDB Gene

IDBG-636955.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHA1

Gene Name

ephrin type-A receptor 1 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006359

Encoded Proteins

IDBP-688940

ephrin type-A receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146904:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:107608325-107623775

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008354

ENSBTAP00000008354

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0001954	positive regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030335	positive regulation of cell migration
GO:0030336	negative regulation of cell migration
GO:0032314	regulation of Rac GTPase activity
GO:0032862	activation of Rho GTPase activity
GO:0034446	substrate adhesion-dependent cell spreading
GO:0045766	positive regulation of angiogenesis
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway
GO:0051496	positive regulation of stress fiber assembly