Version 5.4
Homo sapiens Gene: ARL6
Summary
InnateDB Gene IDBG-46461.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL6
Gene Name ADP-ribosylation factor-like 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000113966
Encoded Proteins
IDBP-46463
ADP-ribosylation factor-like 6
IDBP-242060
ADP-ribosylation factor-like 6
IDBP-479802
ADP-ribosylation factor-like 6
IDBP-473497
ADP-ribosylation factor-like 6
IDBP-478992
ADP-ribosylation factor-like 6
IDBP-483715
ADP-ribosylation factor-like 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-binding site. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:97764521-97801109
Strand Forward strand
Band q11.2
Transcripts
ENST00000335979 ENSP00000337722
ENST00000394206 ENSP00000377756
ENST00000493990 ENSP00000418057
ENST00000463745 ENSP00000419619
ENST00000462412 ENSP00000418740
ENST00000496713
ENST00000476753 ENSP00000419934
ENST00000494363
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0005543 phospholipid binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
Biological Process
GO:0006612 protein targeting to membrane
GO:0006886 intracellular protein transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007368 determination of left/right symmetry
GO:0007601 visual perception
GO:0016055 Wnt signaling pathway
GO:0032402 melanosome transport
GO:0042384 cilium assembly
GO:0045444 fat cell differentiation
GO:0051258 protein polymerization
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005879 axonemal microtubule
GO:0005930 axoneme
GO:0016020 membrane
GO:0030117 membrane coat
GO:0034464 BBSome
GO:0060170 ciliary membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022722
View Gene Order
ENSBTAG00000010091
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.373801 Hs.664939
RefSeq NM_001278293 NM_032146 NM_177976 XM_006713779 XM_006713780 XM_006713782
HUGO
OMIM
CCDS CCDS2928
HPRD 10588
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca