Version 5.4
Bos taurus Gene: ARL6
Summary
InnateDB Gene IDBG-630897.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL6
Gene Name ADP-ribosylation factor-like protein 6
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010091
Encoded Proteins
IDBP-682379
ADP-ribosylation factor-like protein 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113966:
The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-binding site. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:41640353-41679711
Strand Forward strand
Band
Transcripts
ENSBTAT00000013306 ENSBTAP00000013306
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0005543 phospholipid binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0006612 protein targeting to membrane
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0016055 Wnt signaling pathway
GO:0030030 cell projection organization
GO:0042384 cilium assembly
GO:0045444 fat cell differentiation
GO:0051258 protein polymerization
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005879 axonemal microtubule
GO:0005886 plasma membrane
GO:0005930 axoneme
GO:0016020 membrane
GO:0030117 membrane coat
GO:0034464 BBSome
GO:0042995 cell projection
GO:0060170 ciliary membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000113966
View Gene Order
ENSMUSG00000022722
View Gene Order
Cross-References
SwissProt Q0IIM2
TrEMBL
UniProt Splice Variant
Entrez Gene 519014
UniGene Bt.21075
RefSeq NM_001075782 XM_005201180 XM_005201181
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122575
GenPept AAI22576
RNA Seq Atlas 519014

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca