Version 5.4
Homo sapiens Gene: CPOX
Summary
InnateDB Gene IDBG-46912.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPOX
Gene Name coproporphyrinogen oxidase
Synonyms CPO; CPX; HCP
Species Homo sapiens
Ensembl Gene ENSG00000080819
Encoded Proteins
IDBP-46914
coproporphyrinogen oxidase
IDBP-484750
coproporphyrinogen oxidase
IDBP-479694
coproporphyrinogen oxidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:98521132-98593723
Strand Reverse strand
Band q11.2
Transcripts
ENST00000264193 ENSP00000264193
ENST00000512905 ENSP00000425880
ENST00000510489
ENST00000513674 ENSP00000424924
ENST00000515041
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004109 coproporphyrinogen oxidase activity
GO:0005212 structural constituent of eye lens
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006778 porphyrin-containing compound metabolic process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0010035 response to inorganic substance
GO:0010039 response to iron ion
GO:0010288 response to lead ion
GO:0017085 response to insecticide
GO:0044281 small molecule metabolic process
GO:0046685 response to arsenic-containing substance
GO:0051597 response to methylmercury
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022742
View Gene Order
ENSBTAG00000004124
Not yet available
Pathways
NETPATH
REACTOME
REACT_9465
Heme biosynthesis pathway
REACT_9431
Metabolism of porphyrins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00860
Porphyrin and chlorophyll metabolism pathway
INOH
INOH website
Porphyrin metabolism pathway
PID NCI
Cross-References
SwissProt P36551
TrEMBL D6RER6
UniProt Splice Variant
Entrez Gene 1371
UniGene Hs.476982 Hs.700766 Hs.702836 Hs.706297
RefSeq NM_000097
HUGO HGNC:2321
OMIM 612732
CCDS CCDS2932
HPRD
IMGT
EMBL AC021660 AK223481 AK290140 BC017210 BC023551 BC023554 CH471052 D16611 Z28409 Z34531 Z34803 Z34804 Z34805 Z34806 Z34807 Z34808
GenPept AAH17210 AAH23551 AAH23554 BAA04033 BAD97201 BAF82829 CAA82250 CAA84292 EAW79854
RNA Seq Atlas 1371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca