Version 5.4
Homo sapiens Gene: PDLIM3
Summary
InnateDB Gene IDBG-47012.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDLIM3
Gene Name PDZ and LIM domain 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154553
Encoded Proteins
IDBP-47014
PDZ and LIM domain 3
IDBP-47016
PDZ and LIM domain 3
IDBP-47018
PDZ and LIM domain 3
IDBP-484562
PDZ and LIM domain 3
IDBP-484503
PDZ and LIM domain 3
IDBP-811314
PDZ and LIM domain 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:185500660-185535612
Strand Reverse strand
Band q35.1
Transcripts
ENST00000284770 ENSP00000284770
ENST00000284771 ENSP00000284771
ENST00000284767 ENSP00000284767
ENST00000514142
ENST00000514308
ENST00000505886 ENSP00000425138
ENST00000512293 ENSP00000421972
ENST00000504011
ENST00000504355
ENST00000512380
ENST00000515261
ENST00000620787 ENSP00000481771
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008270 zinc ion binding
GO:0008307 structural constituent of muscle
Biological Process
GO:0007015 actin filament organization
GO:0007507 heart development
Cellular Component
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0030018 Z disc
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031636
View Gene Order
ENSBTAG00000017183
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.731826
RefSeq NM_001114107 NM_001257962 NM_001257963 NM_014476
HUGO
OMIM
CCDS CCDS3844 CCDS47172 CCDS75218 CCDS75219
HPRD 08388
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca