Version 5.4
Mus musculus Gene: Pdlim3
Summary
InnateDB Gene IDBG-153234.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pdlim3
Gene Name PDZ and LIM domain 3
Synonyms Actn2lp; AI463105; ALP
Species Mus musculus
Ensembl Gene ENSMUSG00000031636
Encoded Proteins
IDBP-153236
PDZ and LIM domain 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154553:
The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:45885485-45919546
Strand Forward strand
Band B1.1
Transcripts
ENSMUST00000034053 ENSMUSP00000034053
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008270 zinc ion binding
GO:0008307 structural constituent of muscle
Biological Process
GO:0007015 actin filament organization
GO:0007507 heart development
Cellular Component
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0030018 Z disc
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154553
View Gene Order
ENSBTAG00000017183
Not yet available
Cross-References
SwissProt O70209
TrEMBL
UniProt Splice Variant
Entrez Gene 53318
UniGene
RefSeq NM_016798
OMIM
CCDS CCDS22281
HPRD
IMGT
MGI ID MGI:1859274
MGI Symbol Pdlim3
EMBL AF002283 AK078421 BC070418
GenPept AAC16673 AAH70418 BAC37266
RNA Seq Atlas 53318

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca