Version 5.4
Homo sapiens Gene: COL8A1
Summary
InnateDB Gene IDBG-47120.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COL8A1
Gene Name collagen, type VIII, alpha 1
Synonyms C3orf7
Species Homo sapiens
Ensembl Gene ENSG00000144810
Encoded Proteins
IDBP-47122
collagen, type VIII, alpha 1
IDBP-47124
collagen, type VIII, alpha 1
IDBP-381693
collagen, type VIII, alpha 1
IDBP-807192
collagen, type VIII, alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:99638475-99799226
Strand Forward strand
Band q12.1
Transcripts
ENST00000261037 ENSP00000261037
ENST00000273342 ENSP00000273342
ENST00000452013 ENSP00000387589
ENST00000463753
ENST00000483969
ENST00000474648
ENST00000462604
ENST00000621757 ENSP00000482679
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0007155 cell adhesion
GO:0010811 positive regulation of cell-substrate adhesion
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0048593 camera-type eye morphogenesis
GO:0050673 epithelial cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005591 collagen type VIII
GO:0005788 endoplasmic reticulum lumen
GO:0031012 extracellular matrix
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000068196
View Gene Order
ENSBTAG00000013662
Not yet available
Pathways
NETPATH
REACTOME
REACT_13552
Integrin cell surface interactions pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_150401
Collagen degradation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_120729
Collagen formation pathway
KEGG
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654548 Hs.740613 Hs.740617
RefSeq NM_001850 NM_020351
HUGO
OMIM
CCDS CCDS2934
HPRD 00372
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca