Version 5.4
Homo sapiens Gene: KCNC2
Summary
InnateDB Gene IDBG-48506.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNC2
Gene Name potassium voltage-gated channel, Shaw-related subfamily, member 2
Synonyms KV3.2
Species Homo sapiens
Ensembl Gene ENSG00000166006
Encoded Proteins
IDBP-48510
potassium voltage-gated channel, Shaw-related subfamily, member 2
IDBP-48512
potassium voltage-gated channel, Shaw-related subfamily, member 2
IDBP-243924
potassium voltage-gated channel, Shaw-related subfamily, member 2
IDBP-593527
potassium voltage-gated channel, Shaw-related subfamily, member 2
IDBP-594119
potassium voltage-gated channel, Shaw-related subfamily, member 2
IDBP-586297
potassium voltage-gated channel, Shaw-related subfamily, member 2
IDBP-583904
potassium voltage-gated channel, Shaw-related subfamily, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:75040077-75209868
Strand Reverse strand
Band q21.1
Transcripts
ENST00000298972 ENSP00000298972
ENST00000350228 ENSP00000319877
ENST00000393288 ENSP00000376966
ENST00000550433 ENSP00000448301
ENST00000548513 ENSP00000449941
ENST00000549446 ENSP00000449253
ENST00000540018 ENSP00000438423
ENST00000548243
ENST00000546456
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005515 protein binding
Biological Process
GO:0001508 action potential
GO:0006112 energy reserve metabolic process
GO:0006811 ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0044281 small molecule metabolic process
GO:0050796 regulation of insulin secretion
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000035681
View Gene Order
Pathways
NETPATH
REACTOME
REACT_75770
Voltage gated Potassium channels pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q96PR1
TrEMBL
UniProt Splice Variant
Entrez Gene 3747
UniGene Hs.607692 Hs.622586 Hs.741918
RefSeq NM_153748 XM_006719389 NM_001260497 NM_001260498 NM_001260499 NM_139136 NM_139137 XM_006719388
HUGO HGNC:6234
OMIM 176256
CCDS CCDS9006 CCDS58255 CCDS58256 CCDS58257 CCDS9005 CCDS9007
HPRD 08883
IMGT
EMBL AB209994 AC073525 AC091534 AC130405 AF268896 AF268897 AK094720 AK294269 AK309245 AY118169 AY243473 BC093635 BC111991 CH471054
GenPept AAH93635 AAI11992 AAL27272 AAL27273 AAM81577 AAO89503 BAC04407 BAE06076 BAH11717 EAW97287 EAW97288 EAW97289 EAW97291
RNA Seq Atlas 3747

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca