Version 5.4
Homo sapiens Gene: PTPRD
Summary
InnateDB Gene IDBG-49243.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRD
Gene Name protein tyrosine phosphatase, receptor type, D
Synonyms HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA
Species Homo sapiens
Ensembl Gene ENSG00000153707
Encoded Proteins
IDBP-49245
protein tyrosine phosphatase, receptor type, D
IDBP-49247
protein tyrosine phosphatase, receptor type, D
IDBP-49253
protein tyrosine phosphatase, receptor type, D
IDBP-234894
protein tyrosine phosphatase, receptor type, D
IDBP-234896
protein tyrosine phosphatase, receptor type, D
IDBP-234898
protein tyrosine phosphatase, receptor type, D
IDBP-480842
protein tyrosine phosphatase, receptor type, D
IDBP-473369
protein tyrosine phosphatase, receptor type, D
IDBP-480494
protein tyrosine phosphatase, receptor type, D
IDBP-586386
protein tyrosine phosphatase, receptor type, D
IDBP-590726
protein tyrosine phosphatase, receptor type, D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:8314246-10612723
Strand Reverse strand
Band p23
Transcripts
ENST00000381196 ENSP00000370593
ENST00000356435 ENSP00000348812
ENST00000355233 ENSP00000347373
ENST00000397617 ENSP00000380741
ENST00000397611 ENSP00000380735
ENST00000397606 ENSP00000380731
ENST00000486161 ENSP00000417093
ENST00000477552
ENST00000471274
ENST00000488774
ENST00000463477 ENSP00000417661
ENST00000481079 ENSP00000417890
ENST00000537002 ENSP00000440515
ENST00000540109 ENSP00000438164
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0006796 phosphate-containing compound metabolic process
GO:0007157 heterophilic cell-cell adhesion
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0016311 dephosphorylation
GO:0030182 neuron differentiation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0050775 positive regulation of dendrite morphogenesis
GO:0097105 presynaptic membrane assembly
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028399
View Gene Order
ENSBTAG00000010178
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.446083 Hs.599601 Hs.712701
RefSeq NM_001040712 NM_001171025 NM_002839 NM_130391 NM_130392 NM_130393 XM_006716822 XM_006716823 XM_006716824 XM_006716825 XM_006716826 XM_006716829 XM_006716830 XM_006716831 XM_006716832 XM_006716833 XM_006716834 XM_006716835 XM_006716836 XM_006716837 XM_006716838 XM_006716839
HUGO
OMIM
CCDS CCDS43786 CCDS55288 CCDS55289 CCDS55290 CCDS6472 CCDS75813
HPRD 03358
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca