InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PPP1R12A

Summary

InnateDB Gene

IDBG-49402.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1R12A

Gene Name

protein phosphatase 1, regulatory subunit 12A

Synonyms

M130; MBS; MYPT1

Species

Homo sapiens

Ensembl Gene

ENSG00000058272

Encoded Proteins

IDBP-49406

protein phosphatase 1, regulatory subunit 12A

IDBP-380606

protein phosphatase 1, regulatory subunit 12A

IDBP-380608

protein phosphatase 1, regulatory subunit 12A

IDBP-590980

protein phosphatase 1, regulatory subunit 12A

IDBP-583715

protein phosphatase 1, regulatory subunit 12A

IDBP-591725

protein phosphatase 1, regulatory subunit 12A

IDBP-596790

protein phosphatase 1, regulatory subunit 12A

IDBP-593515

protein phosphatase 1, regulatory subunit 12A

IDBP-592220

protein phosphatase 1, regulatory subunit 12A

IDBP-598380

protein phosphatase 1, regulatory subunit 12A

IDBP-589581

protein phosphatase 1, regulatory subunit 12A

IDBP-598345

protein phosphatase 1, regulatory subunit 12A

IDBP-598873

protein phosphatase 1, regulatory subunit 12A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:79773563-79935460

Strand

Reverse strand

Band

q21.31

Transcripts

ENST00000261207	ENSP00000261207
ENST00000450142	ENSP00000389168
ENST00000437004	ENSP00000416769
ENST00000546762	ENSP00000450059
ENST00000550903	ENSP00000449647
ENST00000547253
ENST00000550351
ENST00000550299	ENSP00000449666
ENST00000546369	ENSP00000449514
ENST00000550107	ENSP00000446855
ENST00000548908
ENST00000552892
ENST00000550369
ENST00000551781
ENST00000553081	ENSP00000447144
ENST00000547330	ENSP00000446816
ENST00000550007
ENST00000547131	ENSP00000450061
ENST00000550001
ENST00000550510	ENSP00000447338
ENST00000551191
ENST00000548318	ENSP00000449843

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	69 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0019208	phosphatase regulator activity
GO:0019901	protein kinase binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006470	protein dephosphorylation
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0030155	regulation of cell adhesion
GO:0035507	regulation of myosin-light-chain-phosphatase activity
GO:0043086	negative regulation of catalytic activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046822	regulation of nucleocytoplasmic transport
GO:0051297	centrosome organization

Cellular Component

GO:0000776	kinetochore
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0015629	actin cytoskeleton
GO:0043292	contractile fiber
GO:0072357	PTW/PP1 phosphatase complex