Version 5.4
Homo sapiens Gene: TRPM1
Summary
InnateDB Gene IDBG-4950.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRPM1
Gene Name transient receptor potential cation channel, subfamily M, member 1
Synonyms CSNB1C; LTRPC1; MLSN1
Species Homo sapiens
Ensembl Gene ENSG00000134160
Encoded Proteins
IDBP-4952
transient receptor potential cation channel, subfamily M, member 1
IDBP-234552
transient receptor potential cation channel, subfamily M, member 1
IDBP-599598
transient receptor potential cation channel, subfamily M, member 1
IDBP-598463
transient receptor potential cation channel, subfamily M, member 1
IDBP-585666
transient receptor potential cation channel, subfamily M, member 1
IDBP-583852
transient receptor potential cation channel, subfamily M, member 1
IDBP-587093
transient receptor potential cation channel, subfamily M, member 1
IDBP-591379
transient receptor potential cation channel, subfamily M, member 1
IDBP-596722
transient receptor potential cation channel, subfamily M, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:31001061-31161273
Strand Reverse strand
Band q13.3
Transcripts
ENST00000256552 ENSP00000256552
ENST00000397795 ENSP00000380897
ENST00000560801 ENSP00000453644
ENST00000558768 ENSP00000453119
ENST00000558445 ENSP00000452946
ENST00000559177 ENSP00000453477
ENST00000558212
ENST00000557948
ENST00000560658 ENSP00000454077
ENST00000558070
ENST00000559179 ENSP00000453851
ENST00000542188 ENSP00000437849
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0007216 G-protein coupled glutamate receptor signaling pathway
GO:0007601 visual perception
GO:0034220 ion transmembrane transport
GO:0046548 retinal rod cell development
GO:0055085 transmembrane transport
GO:0060402 calcium ion transport into cytosol
GO:0070588 calcium ion transmembrane transport
GO:0071482 cellular response to light stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0035841 new growing cell tip
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030523
View Gene Order
ENSBTAG00000001639
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
REACT_169333
TRP channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.155942 Hs.732541
RefSeq NM_001252020 NM_001252024 NM_001252030 NM_002420
HUGO
OMIM
CCDS CCDS10024 CCDS58345 CCDS58346 CCDS58347
HPRD 04656
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca