Version 5.4
Homo sapiens Gene: TYRP1
Summary
InnateDB Gene IDBG-49760.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TYRP1
Gene Name tyrosinase-related protein 1
Synonyms b-PROTEIN; CAS2; CATB; GP75; OCA3; TRP; TRP1; TYRP
Species Homo sapiens
Ensembl Gene ENSG00000107165
Encoded Proteins
IDBP-49766
tyrosinase-related protein 1
IDBP-49770
tyrosinase-related protein 1
IDBP-475520
tyrosinase-related protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:12685439-12710290
Strand Forward strand
Band p23
Transcripts
ENST00000381142
ENST00000388918 ENSP00000373570
ENST00000381136 ENSP00000370528
ENST00000473763 ENSP00000419006
ENST00000459790
ENST00000470909
ENST00000473504
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006582 melanin metabolic process
GO:0008152 metabolic process
GO:0030318 melanocyte differentiation
GO:0032438 melanosome organization
GO:0042438 melanin biosynthetic process
GO:0043438 acetoacetic acid metabolic process
GO:0043473 pigmentation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0033162 melanosome membrane
GO:0042470 melanosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005994
View Gene Order
ENSBTAG00000020985
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00350
Tyrosine metabolism pathway
hsa04916
Melanogenesis pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt P17643
TrEMBL B4DNE6 C9JZ52 E7EQI3
UniProt Splice Variant
Entrez Gene 7306
UniGene Hs.270279
RefSeq NM_000550
HUGO HGNC:12450
OMIM 115501
CCDS CCDS34990
HPRD
IMGT
EMBL AF001295 AK297887 AL138753 BC052608 D83059 L38952 X51420 X51455 X60955
GenPept AAC15468 AAC41924 AAH52608 BAA11759 BAG60208 CAA35785 CAA35820 CAA43288
RNA Seq Atlas 7306

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca