Version 5.4
Bos taurus Gene: TYRP1
Summary
InnateDB Gene IDBG-630848.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TYRP1
Gene Name 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020985
Encoded Proteins
IDBP-682334
5,6-dihydroxyindole-2-carboxylic acid oxidase precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107165:
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:31710698-31726956
Strand Reverse strand
Band
Transcripts
ENSBTAT00000027945 ENSBTAP00000027945
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006582 melanin metabolic process
GO:0008152 metabolic process
GO:0030318 melanocyte differentiation
GO:0032438 melanosome organization
GO:0042438 melanin biosynthetic process
GO:0043438 acetoacetic acid metabolic process
GO:0043473 pigmentation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0010008 endosome membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0033162 melanosome membrane
GO:0042470 melanosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000107165
View Gene Order
ENSMUSG00000005994
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00350
Tyrosine metabolism pathway
hsa04916
Melanogenesis pathway
mmu00350
Tyrosine metabolism pathway
mmu04916
Melanogenesis pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL C6KE17 F1MBG9 Q95MD7
UniProt Splice Variant
Entrez Gene 282105
UniGene Bt.221
RefSeq NM_174480
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF398512 DAAA02022458 DAAA02022459 GQ179991
GenPept AAK94986 ACS66870
RNA Seq Atlas 282105

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca