Version 5.4
Homo sapiens Gene: IL2RA
Summary
InnateDB Gene IDBG-50566.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL2RA
Gene Name interleukin 2 receptor, alpha
Synonyms CD25; IDDM10; IL2R; p55; TCGFR
Species Homo sapiens
Ensembl Gene ENSG00000134460
Encoded Proteins
IDBP-50568
interleukin 2 receptor, alpha
IDBP-50570
interleukin 2 receptor, alpha
IDBP-50572
interleukin 2 receptor, alpha
IDBP-364050
interleukin 2 receptor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:6010689-6062325
Strand Reverse strand
Band p15.1
Transcripts
ENST00000379959 ENSP00000369293
ENST00000379954 ENSP00000369287
ENST00000256876 ENSP00000256876
ENST00000447847 ENSP00000402024
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 12 [view]
Protein-DNA 13 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004911 interleukin-2 receptor activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0019976 interleukin-2 binding
Biological Process
GO:0002437 inflammatory response to antigenic stimulus
GO:0006915 apoptotic process
GO:0006924 activation-induced cell death of T cells
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0008283 cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0043029 T cell homeostasis
GO:0045582 positive regulation of T cell differentiation
GO:0046013 regulation of T cell homeostatic proliferation
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050687 negative regulation of defense response to virus
GO:0050728 negative regulation of inflammatory response
GO:0050777 negative regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026770
View Gene Order
ENSBTAG00000020892
Not yet available
Pathways
NETPATH
NetPath_14
IL2 pathway
REACTOME
REACT_23891
Interleukin receptor SHC signaling pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_604
Hemostasis pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04144
Endocytosis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-2 signaling pathway
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
il2_1pathway
IL2-mediated signaling events
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
il12_2pathway
IL12-mediated signaling events
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
il12_stat4pathway
IL12 signaling mediated by STAT4
shp2_pathway
SHP2 signaling
il2_stat5pathway
IL2 signaling events mediated by STAT5
il2_pi3kpathway
IL2 signaling events mediated by PI3K
Cross-References
SwissProt P01589
TrEMBL O15163 Q5W005 Q5W006
UniProt Splice Variant
Entrez Gene 3559
UniGene Hs.231367
RefSeq NM_000417 XM_005252446
HUGO HGNC:6008
OMIM 147730
CCDS CCDS7076
HPRD
IMGT
EMBL AF008556 AL137186 AL157395 AY563103 BN000945 CH471072 K03122 M10322 M11060 M11061 M11062 M11063 M11064 M11065 M11066 M15864 X01057 X03131 X03132 X03133 X03134 X03135 X03136 X03137 X03138
GenPept AAA59162 AAA67527 AAB59535 AAB63458 AAS55572 CAA25525 CAA26906 CAH73595 CAI41069 CAK26553 EAW86413 EAW86414
RNA Seq Atlas 3559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca