Homo sapiens Gene: IL2RA
Summary
InnateDB Gene IDBG-50566.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL2RA
Gene Name interleukin 2 receptor, alpha
Synonyms CD25; IDDM10; IL2R; p55; TCGFR;
Species Homo sapiens
Ensembl Gene ENSG00000134460
Encoded Proteins
interleukin 2 receptor, alpha
interleukin 2 receptor, alpha
interleukin 2 receptor, alpha
interleukin 2 receptor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:6010689-6062325
Strand Reverse strand
Band p15.1
Transcripts
ENST00000379959 ENSP00000369293
ENST00000379954 ENSP00000369287
ENST00000256876 ENSP00000256876
ENST00000447847 ENSP00000402024
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 12 [view]
Protein-DNA 13 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004911 interleukin-2 receptor activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0019976 interleukin-2 binding
Biological Process
GO:0002437 inflammatory response to antigenic stimulus
GO:0006915 apoptotic process
GO:0006924 activation-induced cell death of T cells
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0008283 cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0043029 T cell homeostasis
GO:0045582 positive regulation of T cell differentiation
GO:0046013 regulation of T cell homeostatic proliferation
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050687 negative regulation of defense response to virus
GO:0050728 negative regulation of inflammatory response
GO:0050777 negative regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
IL2 pathway
REACTOME
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
GPVI-mediated activation cascade pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
G beta:gamma signalling through PI3Kgamma pathway
Hemostasis pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Endocytosis pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
INOH
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
PID BIOCARTA
Il 2 signaling pathway [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
PID NCI
Calcium signaling in the CD4+ TCR pathway
IL2-mediated signaling events
Downstream signaling in na´ve CD8+ T cells
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
IL12 signaling mediated by STAT4
SHP2 signaling
IL2 signaling events mediated by STAT5
IL2 signaling events mediated by PI3K
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.231367
RefSeq NM_000417 XM_005252446
HUGO
OMIM
CCDS CCDS7076
HPRD 00986
IMGT
EMBL
GenPept
RNA Seq Atlas