Version 5.4
Homo sapiens Gene: ATP6V0A1
Summary
InnateDB Gene IDBG-50881.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP6V0A1
Gene Name ATPase, H+ transporting, lysosomal V0 subunit a1
Synonyms a1; ATP6N1; ATP6N1A; Stv1; Vph1; VPP1
Species Homo sapiens
Ensembl Gene ENSG00000033627
Encoded Proteins
IDBP-50883
ATPase, H+ transporting, lysosomal V0 subunit a1
IDBP-50885
ATPase, H+ transporting, lysosomal V0 subunit a1
IDBP-242821
ATPase, H+ transporting, lysosomal V0 subunit a1
IDBP-592230
ATPase, H+ transporting, lysosomal V0 subunit a1
IDBP-587979
ATPase, H+ transporting, lysosomal V0 subunit a1
IDBP-763221
IDBP-762521
IDBP-761784
IDBP-758180
IDBP-758643
IDBP-763786
IDBP-761161
IDBP-758693
IDBP-764454
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42458844-42522611
Strand Forward strand
Band q21.2
Transcripts
ENST00000264649 ENSP00000264649
ENST00000343619 ENSP00000342951
ENST00000393829 ENSP00000377415
ENST00000537728 ENSP00000443991
ENST00000544137 ENSP00000446377
ENST00000588901 ENSP00000468001
ENST00000586201 ENSP00000468177
ENST00000588138 ENSP00000466852
ENST00000587824 ENSP00000466328
ENST00000587797
ENST00000592831
ENST00000589727 ENSP00000467373
ENST00000588806
ENST00000587510 ENSP00000468169
ENST00000589213 ENSP00000466290
ENST00000592324 ENSP00000466767
ENST00000587375
ENST00000589759
ENST00000587299
ENST00000588629
ENST00000585525 ENSP00000466878
ENST00000586315
ENST00000586001
ENST00000585828
ENST00000587882
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0051117 ATPase binding
Biological Process
GO:0006879 cellular iron ion homeostasis
GO:0008286 insulin receptor signaling pathway
GO:0015991 ATP hydrolysis coupled proton transport
GO:0033572 transferrin transport
GO:0051701 interaction with host
GO:0055085 transmembrane transport
GO:0090382 phagosome maturation
Cellular Component
GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0030670 phagocytic vesicle membrane
GO:0033179 proton-transporting V-type ATPase, V0 domain
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019302
View Gene Order
ENSBTAG00000019218
Not yet available
Pathways
NETPATH
REACTOME
REACT_25283
Transferrin endocytosis and recycling pathway
REACT_25060
Iron uptake and transport pathway
REACT_1109
Insulin receptor recycling pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_121256
Phagosomal maturation (early endosomal stage) pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111102
Signal Transduction pathway
REACT_121237
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_116125
Disease pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa00190
Oxidative phosphorylation pathway
hsa04142
Lysosome pathway
hsa04966
Collecting duct acid secretion pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 535
UniGene Hs.463074
RefSeq NM_001130020 NM_001130021 NM_005177 XM_005257459
HUGO HGNC:865
OMIM 192130
CCDS CCDS11426 CCDS45683 CCDS45684
HPRD 01886
IMGT
EMBL
GenPept
RNA Seq Atlas 102723826 535

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca