Version 5.4
Homo sapiens Gene: PLD3
Summary
InnateDB Gene IDBG-51389.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLD3
Gene Name phospholipase D family, member 3
Synonyms AD19; HU-K4; HUK4
Species Homo sapiens
Ensembl Gene ENSG00000105223
Encoded Proteins
IDBP-51391
phospholipase D family, member 3
IDBP-51393
phospholipase D family, member 3
IDBP-246485
phospholipase D family, member 3
IDBP-294855
phospholipase D family, member 3
IDBP-294853
phospholipase D family, member 3
IDBP-294846
phospholipase D family, member 3
IDBP-294850
phospholipase D family, member 3
IDBP-764584
IDBP-762608
IDBP-765196
IDBP-759856
IDBP-765115
IDBP-759869
IDBP-764716
IDBP-766104
IDBP-765786
IDBP-760778
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:40348456-40380439
Strand Forward strand
Band q13.2
Transcripts
ENST00000356508 ENSP00000348901
ENST00000359274 ENSP00000352220
ENST00000392032 ENSP00000375886
ENST00000409419 ENSP00000386293
ENST00000409587 ENSP00000387050
ENST00000409735 ENSP00000386938
ENST00000409281 ENSP00000387022
ENST00000493006
ENST00000464586
ENST00000485448
ENST00000492243 ENSP00000469868
ENST00000480030
ENST00000475983
ENST00000488311
ENST00000486134 ENSP00000473218
ENST00000602131 ENSP00000468999
ENST00000599353 ENSP00000472854
ENST00000594908 ENSP00000471838
ENST00000599685 ENSP00000469675
ENST00000596470 ENSP00000470569
ENST00000600479
ENST00000600948 ENSP00000472509
ENST00000594085
ENST00000596682 ENSP00000468898
ENST00000598962 ENSP00000470603
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004630 phospholipase D activity
GO:0005515 protein binding
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006655 phosphatidylglycerol biosynthetic process
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003363
View Gene Order
ENSBTAG00000019150
Not yet available
Pathways
NETPATH
REACTOME
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_121280
Synthesis of PG pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6802
Innate Immune System pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_6900
Immune System pathway
REACT_120870
Phospholipid metabolism pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa00565
Ether lipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001031696 NM_001291311 NM_012268 XM_005258704 XM_005258705 XM_005258706 XM_005258707 XM_005258708 XM_005258709 XM_005258710 XM_006723121 XM_006723122 XM_006723123 XM_006723124
HUGO
OMIM
CCDS CCDS33027
HPRD 07148
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca