InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PLD3

Summary

InnateDB Gene

IDBG-637899.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLD3

Gene Name

Phospholipase D3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019150

Encoded Proteins

IDBP-689933

Phospholipase D3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105223:
This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:49995631-50005033

Strand

Forward strand

Band

Transcripts

ENSBTAT00000044153

ENSBTAP00000041666

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004630	phospholipase D activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity

Biological Process

GO:0006629	lipid metabolic process
GO:0008152	metabolic process
GO:0016042	lipid catabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome