Version 5.4
Homo sapiens Gene: ITIH5
Summary
InnateDB Gene IDBG-51501.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITIH5
Gene Name inter-alpha-trypsin inhibitor heavy chain family, member 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000123243
Encoded Proteins
IDBP-235977
inter-alpha (globulin) inhibitor H5
IDBP-235979
inter-alpha (globulin) inhibitor H5
IDBP-482240
inter-alpha (globulin) inhibitor H5
IDBP-807506
inter-alpha-trypsin inhibitor heavy chain family, member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:7559270-7666998
Strand Reverse strand
Band p14
Transcripts
ENST00000397146 ENSP00000380333
ENST00000397145 ENSP00000380332
ENST00000434980
ENST00000473591
ENST00000492668
ENST00000468389
ENST00000476417
ENST00000461751 ENSP00000419386
ENST00000613909 ENSP00000485414
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0030212 hyaluronan metabolic process
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025780
View Gene Order
ENSBTAG00000013004
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001001851 NM_030569 NM_032817
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca