Version 5.4
Bos taurus Gene: BT.43334
Summary
InnateDB Gene IDBG-636981.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.43334
Gene Name inter-alpha-trypsin inhibitor heavy chain H5 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013004
Encoded Proteins
IDBP-688968
inter-alpha-trypsin inhibitor heavy chain H5 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123243:
This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:16278275-16404464
Strand Forward strand
Band
Transcripts
ENSBTAT00000048699 ENSBTAP00000045691
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030212 hyaluronan metabolic process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000123243
View Gene Order
ENSMUSG00000025780
View Gene Order
Cross-References
SwissProt
TrEMBL F1N1Z6
UniProt Splice Variant
Entrez Gene 534787
UniGene Bt.43334
RefSeq NM_001102516
HUGO HGNC:21449
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02035310 DAAA02035311 DAAA02035312 DAAA02035313 DAAA02035314 DAAA02035315 DAAA02035316 DAAA02035317 DAAA02035318
GenPept
RNA Seq Atlas 534787

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca