Homo sapiens Gene: WNK4
Summary
InnateDB Gene IDBG-51675.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WNK4
Gene Name WNK lysine deficient protein kinase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000126562
Encoded Proteins
WNK lysine deficient protein kinase 4
Protein Structure
Entrez Gene
Summary This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42780678-42796936
Strand Forward strand
Band q21.2
Transcripts
ENST00000246914 ENSP00000246914
ENST00000591448 ENSP00000467088
ENST00000587705
ENST00000587745 ENSP00000467312
ENST00000592072
ENST00000592669
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019869 chloride channel inhibitor activity
Biological Process
GO:0006468 protein phosphorylation
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0008104 protein localization
GO:0035556 intracellular signal transduction
GO:0050794 regulation of cellular process
GO:0050801 ion homeostasis
GO:0070294 renal sodium ion absorption
GO:0072156 distal tubule morphogenesis
GO:0090188 negative regulation of pancreatic juice secretion
Cellular Component
GO:0005737 cytoplasm
GO:0005923 tight junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Stimuli-sensing channels pathway
Ion channel transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96J92
TrEMBL K7ENT7 K7EPB3
UniProt Splice Variant
Entrez Gene 65266
UniGene Hs.105448
RefSeq NM_032387 XM_005257595 XM_005257596 XM_005257597 XM_006722022
HUGO HGNC:14544
OMIM 601844
CCDS CCDS11439
HPRD 03505
IMGT
EMBL AC016889 AC100793 AF390018 AJ309861 AJ316534 AK096003 AK096052 BC136664 CH471152 EU332870
GenPept AAI36665 AAK91995 ABY87559 BAC04669 BAC04688 CAC32991 CAC48387 EAW60881 EAW60882
ImmGen WNK4 (murine)
RNA Seq Atlas 102724304 65266