Homo sapiens Gene: WNK4

Summary
InnateDB Gene IDBG-51675.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol WNK4
Gene Name WNK lysine deficient protein kinase 4
Synonyms PHA2B; PRKWNK4
Species Homo sapiens
Ensembl Gene ENSG00000126562
Encoded Proteins
IDBP-51677 WNK lysine deficient protein kinase 4
IDBP-764095
IDBP-757752
Entrez Gene
Summary This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17: 40932696-40948954
Strand Forward strand
Band q21.31
Transcripts
ENST00000246914  ENSP00000246914
ENST00000591448  ENSP00000467088
ENST00000587705 
ENST00000587745  ENSP00000467312
ENST00000592072 
ENST00000592669 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein‑Protein  16
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 1
[view]
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0007243 intracellular protein kinase cascade
GO:0008104 protein localization
GO:0050794 regulation of cellular process
GO:0090188 negative regulation of pancreatic juice secretion
Cellular Component
GO:0005737 cytoplasm
GO:0005923 tight junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000035112 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000019907 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_160189 Stimuli-sensing channels
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96J92 
TrEMBL B0LPI0
UniProt Splice Variant
Entrez Gene 65266 
UniGene Hs.105448
RefSeq NM_032387 
HUGO 14544 
OMIM 601844
CCDS CCDS11439 
HPRD 03505
IMGT
EMBL AF390018 AJ309861 AJ316534 AK096003 AK096052 BC136664 CH471152 EU332870
GenPept AAI36665  AAK91995  ABY87559  BAC04669  BAC04688  CAC32991  CAC48387  EAW60881 
ImmGen WNK4 (murine) 
RNA Seq Atlas 65266