Version 5.4
Homo sapiens Gene: NUMBL
Summary
InnateDB Gene IDBG-52025.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUMBL
Gene Name numb homolog (Drosophila)-like
Synonyms CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR; TNRC23
Species Homo sapiens
Ensembl Gene ENSG00000105245
Encoded Proteins
IDBP-52027
numb homolog (Drosophila)-like
IDBP-603168
numb homolog (Drosophila)-like
IDBP-763460
IDBP-764583
IDBP-760508
IDBP-766232
IDBP-760249
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18299187
NUMBL interacts with TAB2 (MAP3K7IP2) and inhibits TNF alpha and IL-1Beta-induced NF-kappaB activation.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:40665905-40690972
Strand Reverse strand
Band q13.2
Transcripts
ENST00000252891 ENSP00000252891
ENST00000540131 ENSP00000442759
ENST00000599786
ENST00000600967 ENSP00000469310
ENST00000598759
ENST00000593367
ENST00000599594
ENST00000598773 ENSP00000469736
ENST00000598779 ENSP00000472400
ENST00000595741 ENSP00000470794
ENST00000600636 ENSP00000471376
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007399 nervous system development
GO:0007405 neuroblast proliferation
GO:0007409 axonogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0019538 protein metabolic process
GO:0021670 lateral ventricle development
GO:0021849 neuroblast division in subventricular zone
GO:0030900 forebrain development
GO:0034332 adherens junction organization
GO:0045087 innate immune response (InnateDB)
GO:0050769 positive regulation of neurogenesis
GO:0050775 positive regulation of dendrite morphogenesis
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063160
View Gene Order
ENSBTAG00000019461
Not yet available
Pathways
NETPATH
NetPath_3
Notch pathway
REACTOME
KEGG
hsa04330
Notch signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.326953
RefSeq NM_001289979 NM_001289980 NM_004756 XM_006723471
HUGO
OMIM
CCDS CCDS12561
HPRD 04931
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca