InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SOST

Summary

InnateDB Gene

IDBG-52907.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOST

Gene Name

sclerostin

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000167941

Encoded Proteins

IDBP-52909

sclerostin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:43753731-43758788

Strand

Reverse strand

Band

q21.31

Transcripts

ENST00000301691

ENSP00000301691

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008201	heparin binding

Biological Process

GO:0001503	ossification
GO:0009612	response to mechanical stimulus
GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030279	negative regulation of ossification
GO:0030514	negative regulation of BMP signaling pathway
GO:0031333	negative regulation of protein complex assembly
GO:0045893	positive regulation of transcription, DNA-templated
GO:0071374	cellular response to parathyroid hormone stimulus
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000054	negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification