InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sost

Summary

InnateDB Gene

IDBG-212397.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sost

Gene Name

sclerostin

Synonyms

5430411E23Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001494

Encoded Proteins

IDBP-212399

sclerostin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167941:
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:101962458-101967015

Strand

Reverse strand

Band

Transcripts

ENSMUST00000001534

ENSMUSP00000001534

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0001503	ossification
GO:0009612	response to mechanical stimulus
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030279	negative regulation of ossification
GO:0030514	negative regulation of BMP signaling pathway
GO:0031333	negative regulation of protein complex assembly
GO:0045893	positive regulation of transcription, DNA-templated
GO:0071374	cellular response to parathyroid hormone stimulus
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000054	negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification

Cellular Component

GO:0005615	extracellular space
GO:0005794	Golgi apparatus
GO:0031012	extracellular matrix

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000167941

View Gene Order

ENSBTAG00000013134

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04310

Wnt signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_228096

misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway

REACT_228331

Signaling by WNT in cancer pathway

REACT_11045

Signaling by Wnt pathway

REACT_111102

Signal Transduction pathway

REACT_200643

negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway

REACT_200777

TCF dependent signaling in response to WNT pathway

REACT_228188

RNF mutants show enhanced WNT signaling and proliferation pathway

REACT_228279

XAV939 inhibits tankyrase, stabilizing AXIN pathway

REACT_116125

Disease pathway

KEGG

hsa04310

Wnt signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

B2RQA5

UniProt Splice Variant

Entrez Gene

74499

UniGene

Mm.265602

RefSeq

NM_024449 XM_006534376

OMIM

CCDS

CCDS25481

HPRD

IMGT

MGI ID

MGI:1921749

MGI Symbol

Sost

EMBL

AL591145 BC137832 BC137833 CH466558 FQ790373

GenPept

AAI37833 AAI37834 EDL34073

RNA Seq Atlas

74499