Version 5.4
Homo sapiens Gene: TOM1
Summary
InnateDB Gene IDBG-5330.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOM1
Gene Name target of myb1 (chicken)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100284
Encoded Proteins
IDBP-5334
target of myb1 (chicken)
IDBP-238936
target of myb1 (chicken)
IDBP-294193
target of myb1 (chicken)
IDBP-374144
target of myb1 (chicken)
IDBP-374145
target of myb1 (chicken)
IDBP-374151
target of myb1 (chicken)
IDBP-374153
target of myb1 (chicken)
IDBP-374154
target of myb1 (chicken)
IDBP-374171
target of myb1 (chicken)
IDBP-374173
target of myb1 (chicken)
IDBP-374175
target of myb1 (chicken)
IDBP-374177
target of myb1 (chicken)
IDBP-813448
target of myb1 (chicken)
IDBP-813449
target of myb1 (chicken)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:35299275-35347994
Strand Forward strand
Band q12.3
Transcripts
ENST00000382034 ENSP00000371465
ENST00000395736 ENSP00000379085
ENST00000404284 ENSP00000385906
ENST00000447733 ENSP00000398876
ENST00000456128 ENSP00000393714
ENST00000411850 ENSP00000413697
ENST00000449058 ENSP00000394466
ENST00000425375 ENSP00000394924
ENST00000439512 ENSP00000394944
ENST00000424387 ENSP00000397492
ENST00000449508 ENSP00000390429
ENST00000443206 ENSP00000389789
ENST00000465529
ENST00000487670
ENST00000497448
ENST00000491987
ENST00000492723
ENST00000608749 ENSP00000476698
ENST00000608674 ENSP00000477471
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 38 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030276 clathrin binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0016197 endosomal transport
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037827
View Gene Order
ENSBTAG00000045785
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt O60784
TrEMBL B0QY02 V9GYF4 V9GZ68
UniProt Splice Variant
Entrez Gene 10043
UniGene Hs.474705
RefSeq NM_001135732 NM_001135729 NM_001135730 NM_005488
HUGO HGNC:11982
OMIM 604700
CCDS CCDS46696 CCDS13913 CCDS46697 CCDS46698
HPRD 05265
IMGT
EMBL AJ006973 AK293694 AK297827 AL008635 BC046151 CH471095 CR456595 Z82244
GenPept AAH46151 BAG57130 BAG60163 CAA07362 CAG30481 CAI17951 CAI21633 EAW60055
RNA Seq Atlas 10043

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca