InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCT4

Summary

InnateDB Gene

IDBG-53426.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCT4

Gene Name

chaperonin containing TCP1, subunit 4 (delta)

Synonyms

CCT-DELTA; Cctd; SRB

Species

Homo sapiens

Ensembl Gene

ENSG00000115484

Encoded Proteins

IDBP-241576

chaperonin containing TCP1, subunit 4 (delta)

IDBP-597232

chaperonin containing TCP1, subunit 4 (delta)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:61868089-61888804

Strand

Reverse strand

Band

p15

Transcripts

ENST00000394440	ENSP00000377958
ENST00000461540
ENST00000461370
ENST00000544079	ENSP00000443061

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 116 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	116 [view]
Protein-Protein	115 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007339	binding of sperm to zona pellucida
GO:0044267	cellular protein metabolic process
GO:0051084	'de novo' posttranslational protein folding

Cellular Component

GO:0002199	zona pellucida receptor complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005832	chaperonin-containing T-complex
GO:0005874	microtubule
GO:0042470	melanosome
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome