Version 5.4
Homo sapiens Gene: OPTN
Summary
InnateDB Gene IDBG-54466.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OPTN
Gene Name optineurin
Synonyms ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP
Species Homo sapiens
Ensembl Gene ENSG00000123240
Encoded Proteins
IDBP-54468
optineurin
IDBP-54470
optineurin
IDBP-54472
optineurin
IDBP-54474
optineurin
IDBP-54476
optineurin
IDBP-54478
optineurin
IDBP-366066
optineurin
IDBP-366070
optineurin
IDBP-807000
optineurin
IDBP-807009
optineurin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20174559
OPTN (optineurin) has a role in the inhibition of virus-triggered IFNB1 induction.
Entrez Gene
Summary This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:13099449-13138308
Strand Forward strand
Band p13
Transcripts
ENST00000263036 ENSP00000263036
ENST00000378764 ENSP00000368040
ENST00000378757 ENSP00000368032
ENST00000378748 ENSP00000368022
ENST00000378752 ENSP00000368027
ENST00000378747 ENSP00000368021
ENST00000430081 ENSP00000414747
ENST00000424614 ENSP00000400356
ENST00000487935
ENST00000482140 ENSP00000484961
ENST00000486862 ENSP00000481473
ENST00000469025
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 103 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 103 [view]
Protein-Protein 103 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0031593 polyubiquitin binding
Biological Process
GO:0000042 protein targeting to Golgi
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0001920 negative regulation of receptor recycling
GO:0007030 Golgi organization
GO:0007165 signal transduction
GO:0008219 cell death
GO:0016236 macroautophagy
GO:0034613 cellular protein localization
GO:0043001 Golgi to plasma membrane protein transport
GO:0045087 innate immune response (InnateDB)
GO:0050829 defense response to Gram-negative bacterium
GO:0090161 Golgi ribbon formation
Cellular Component
GO:0000139 Golgi membrane
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026672
View Gene Order
ENSBTAG00000016401
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_115566
Cell Cycle pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.332706
RefSeq NM_001008211 NM_001008212 NM_001008213 NM_021980 XM_005252336 XM_005252337 XM_005252338
HUGO
OMIM
CCDS CCDS7094
HPRD 03891
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca