Bos taurus Gene: OPTN | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||
InnateDB Gene | IDBG-637914.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | OPTN | ||||||||||||||||
Gene Name | optineurin | ||||||||||||||||
Synonyms | |||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000016401 | ||||||||||||||||
Encoded Proteins |
optineurin
|
||||||||||||||||
Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||
Summary |
[Homo sapiens] OPTN (optineurin) has a role in the inhibition of virus-triggered IFNB1 induction.
|
||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123240:
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
||||||||||||||||
Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 13:28078762-28117627 | ||||||||||||||||
Strand | Forward strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
|
||||||||||||||||
Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
|
||||||||||||||||
Gene Ontology | |||||||||||||||||
Molecular Function |
|
||||||||||||||||
Biological Process |
|
||||||||||||||||
Cellular Component |
|
||||||||||||||||
Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH |
TSLP pathway
|
||||||||||||||||
REACTOME |
Regulation of PLK1 Activity at G2/M Transition pathway
Cell Cycle pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Cell Cycle pathway
Mitotic G2-G2/M phases pathway
Regulation of PLK1 Activity at G2/M Transition pathway
|
||||||||||||||||
KEGG | |||||||||||||||||
INOH | |||||||||||||||||
PID NCI | |||||||||||||||||
Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | Q3ZC32 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 534150 | ||||||||||||||||
UniGene | Bt.49466 | ||||||||||||||||
RefSeq | NM_001034602 XM_005214208 XM_005214209 XM_005214210 XM_005214211 XM_005214212 XM_005214213 | ||||||||||||||||
HUGO | |||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | BC102937 DAAA02035514 | ||||||||||||||||
GenPept | AAI02938 | ||||||||||||||||
RNA Seq Atlas | 534150 | ||||||||||||||||