Version 5.4
Homo sapiens Gene: GRIA1
Summary
InnateDB Gene IDBG-54739.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRIA1
Gene Name glutamate receptor, ionotropic, AMPA 1
Synonyms GluA1; GLUH1; GLUR1; GLURA; HBGR1
Species Homo sapiens
Ensembl Gene ENSG00000155511
Encoded Proteins
IDBP-54741
glutamate receptor, ionotropic, AMPA 1
IDBP-54743
glutamate receptor, ionotropic, AMPA 1
IDBP-379281
glutamate receptor, ionotropic, AMPA 1
IDBP-477433
glutamate receptor, ionotropic, AMPA 1
IDBP-478965
glutamate receptor, ionotropic, AMPA 1
IDBP-475783
glutamate receptor, ionotropic, AMPA 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:153489615-153813869
Strand Forward strand
Band q33.2
Transcripts
ENST00000285900 ENSP00000285900
ENST00000340592 ENSP00000339343
ENST00000448073 ENSP00000415569
ENST00000481559
ENST00000520353
ENST00000518862
ENST00000474198
ENST00000518142 ENSP00000427920
ENST00000517469
ENST00000521843 ENSP00000427864
ENST00000518783 ENSP00000428994
ENST00000492291
ENST00000520966
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004970 ionotropic glutamate receptor activity
GO:0004971 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005515 protein binding
GO:0008066 glutamate receptor activity
GO:0030165 PDZ domain binding
Biological Process
GO:0006810 transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0007616 long-term memory
GO:0031623 receptor internalization
GO:0034220 ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0008328 ionotropic glutamate receptor complex
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0030666 endocytic vesicle membrane
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0032590 dendrite membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0044308 axonal spine
GO:0044309 neuron spine
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020524
View Gene Order
ENSBTAG00000005800
Not yet available
Pathways
NETPATH
REACTOME
REACT_20594
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_18422
Trafficking of GluR2-containing AMPA receptors pathway
REACT_18307
Trafficking of AMPA receptors pathway
REACT_18338
Activation of AMPA receptors pathway
REACT_13685
Neuronal System pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_18347
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04720
Long-term potentiation pathway
hsa04730
Long-term depression pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
INOH
PID NCI
Cross-References
SwissProt P42261
TrEMBL
UniProt Splice Variant
Entrez Gene 2890
UniGene Hs.519693 Hs.737709
RefSeq NM_001258021 NM_000827 NM_001114183 NM_001258019 NM_001258020 NM_001258022 NM_001258023
HUGO HGNC:4571
OMIM 138248
CCDS CCDS58987 CCDS4322 CCDS47318 CCDS58986 CCDS58988 CCDS58989
HPRD 00695
IMGT
EMBL AC010613 AC025156 AC091960 AC091962 AK295039 AK295184 AK295827 AK315934 BC111734 CH471062 M64752 M81886 X58633
GenPept AAA58395 AAA58613 AAI11735 BAH11956 BAH12004 BAH12192 BAH14305 CAA41491 EAW61649 EAW61650
RNA Seq Atlas 2890

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca