Version 5.4
Bos taurus Gene: GRIA1
Summary
InnateDB Gene IDBG-646348.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRIA1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005800
Encoded Proteins
IDBP-699146
glutamate receptor, ionotropic, AMPA 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155511:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:66766525-67109288
Strand Forward strand
Band
Transcripts
ENSBTAT00000007628 ENSBTAP00000007628
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004970 ionotropic glutamate receptor activity
GO:0004971 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:0005215 transporter activity
GO:0005216 ion channel activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007268 synaptic transmission
GO:0007616 long-term memory
GO:0031623 receptor internalization
GO:0034220 ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0008328 ionotropic glutamate receptor complex
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0032590 dendrite membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0044308 axonal spine
GO:0044309 neuron spine
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000155511
View Gene Order
ENSMUSG00000020524
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20594
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_18422
Trafficking of GluR2-containing AMPA receptors pathway
REACT_18307
Trafficking of AMPA receptors pathway
REACT_18338
Activation of AMPA receptors pathway
REACT_13685
Neuronal System pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_18347
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
REACT_252788
Activation of AMPA receptors pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_232605
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
REACT_259290
Neuronal System pathway
REACT_258217
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_253367
Trafficking of GluR2-containing AMPA receptors pathway
REACT_244428
Trafficking of AMPA receptors pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_214376
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04720
Long-term potentiation pathway
hsa04730
Long-term depression pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04720
Long-term potentiation pathway
mmu04730
Long-term depression pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N3G8
UniProt Splice Variant
Entrez Gene 529618
UniGene Bt.110838
RefSeq XM_002689318 XM_002689319 XM_002704887
HUGO HGNC:4571
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02020690 DAAA02020691 DAAA02020692 DAAA02020693 DAAA02020694 DAAA02020695 DAAA02020696 DAAA02020697 DAAA02020698 DAAA02020699 DAAA02020700 DAAA02020701 DAAA02020702
GenPept
RNA Seq Atlas 529618

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca