Homo sapiens Gene: PAIP2B
Summary
InnateDB Gene IDBG-55917.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAIP2B
Gene Name poly(A) binding protein interacting protein 2B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124374
Encoded Proteins
poly(A) binding protein interacting protein 2B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:71182739-71227083
Strand Reverse strand
Band p13.3
Transcripts
ENST00000244221 ENSP00000244221
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000900 translation repressor activity, nucleic acid binding
GO:0005515 protein binding
Biological Process
GO:0045947 negative regulation of translational initiation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt Q9ULR5
TrEMBL
UniProt Splice Variant
Entrez Gene 400961
UniGene Hs.416735 Hs.606029 Hs.694889
RefSeq NM_020459 XM_005264310 XM_005264311
HUGO HGNC:29200
OMIM 611018
CCDS CCDS46322
HPRD
IMGT
EMBL AB032981
GenPept BAA86469
RNA Seq Atlas 400961