InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GIP

Summary

InnateDB Gene

IDBG-57393.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GIP

Gene Name

gastric inhibitory polypeptide

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000159224

Encoded Proteins

IDBP-57395

gastric inhibitory polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:48958554-48968596

Strand

Reverse strand

Band

q21.32

Transcripts

ENST00000357424

ENSP00000350005

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity

Biological Process

GO:0001101	response to acid
GO:0007165	signal transduction
GO:0007565	female pregnancy
GO:0007613	memory
GO:0008344	adult locomotory behavior
GO:0009743	response to carbohydrate
GO:0009749	response to glucose
GO:0010269	response to selenium ion
GO:0010828	positive regulation of glucose transport
GO:0014070	response to organic cyclic compound
GO:0019233	sensory perception of pain
GO:0031018	endocrine pancreas development
GO:0031667	response to nutrient levels
GO:0032024	positive regulation of insulin secretion
GO:0033993	response to lipid
GO:0035640	exploration behavior
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0043200	response to amino acid
GO:0043434	response to peptide hormone
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0044267	cellular protein metabolic process
GO:0048678	response to axon injury
GO:0050796	regulation of insulin secretion
GO:0050806	positive regulation of synaptic transmission
GO:0055123	digestive system development
GO:0060291	long-term synaptic potentiation
GO:0070094	positive regulation of glucagon secretion
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0034774	secretory granule lumen
GO:0043025	neuronal cell body