Homo sapiens Gene: MAOA
Summary
InnateDB Gene IDBG-58306.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol MAOA
Gene Name monoamine oxidase A
Synonyms MAO-A;
Species Homo sapiens
Ensembl Gene ENSG00000189221
Encoded Proteins
monoamine oxidase A
monoamine oxidase A
Protein Structure
Entrez Gene
Summary This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:43515467-43606068
Strand Forward strand
Band p11.3
Transcripts
ENST00000338702 ENSP00000340684
ENST00000497485
ENST00000490604
ENST00000542639 ENSP00000440846
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008131 primary amine oxidase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0051378 serotonin binding
Biological Process
GO:0006576 cellular biogenic amine metabolic process
GO:0006805 xenobiotic metabolic process
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007610 behavior
GO:0042135 neurotransmitter catabolic process
GO:0042136 neurotransmitter biosynthetic process
GO:0042420 dopamine catabolic process
GO:0042428 serotonin metabolic process
GO:0042443 phenylethylamine metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral to membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2 pathway
Norepinephrine Neurotransmitter Release Cycle pathway
Enzymatic degradation of Dopamine by monoamine oxidase pathway
Metabolism of serotonin pathway
Enzymatic degradation of dopamine by COMT pathway
KEGG
Arginine and proline metabolism pathway
Glycine, serine and threonine metabolism pathway
Tryptophan metabolism pathway
Tyrosine metabolism pathway
Histidine metabolism pathway
Phenylalanine metabolism pathway
Drug metabolism - cytochrome P450 pathway
Metabolic pathways pathway
INOH
Phenylalanine degradation pathway
Tryptophan degradation pathway
Arginine Proline metabolism pathway
Glycine Serine metabolism pathway
Tyrosine metabolism pathway
Histidine degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P21397
TrEMBL B4DF46 Q53YE7 Q5UL91 Q5UL94 Q5ULA3 Q5ULA9
UniProt Splice Variant
Entrez Gene 4128
UniGene Hs.183109 Hs.653990
RefSeq NM_000240 NM_001270458
HUGO 6833
OMIM 309850
CCDS CCDS14260
HPRD 02400
IMGT
EMBL AK291769 AK293926 AL109855 AY684850 AY684858 AY685682 AY685685 BC008064 BT006651 BX530072 BX537147 BX537148 CH471141 M68840 M68843 M68844 M68845 M68846 M68847 M68848 M68849 M68850 M68851 M68852 M68853 M68854 M68855 M68856 M68857 M69226 M89636 S72704 S81371 X60806 X60807 X60808 X60809 X60810 X60811 X60812 X60813 X60814 X60815 X60816 X60817 X60818 X60819
GenPept AAA59547 AAA59548 AAA59549 AAB46385 AAD14113 AAD14361 AAH08064 AAP35297 AAV34705 AAV34711 AAV34717 AAV34720 BAF84458 BAG57307 CAI42421 CAI42424 EAW59381 EAW59383
ImmGen MAOA (murine)
RNA Seq Atlas 4128