InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAOA

Summary

InnateDB Gene

IDBG-58306.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAOA

Gene Name

monoamine oxidase A

Synonyms

MAO-A

Species

Homo sapiens

Ensembl Gene

ENSG00000189221

Encoded Proteins

IDBP-58308

monoamine oxidase A

IDBP-587498

monoamine oxidase A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:43654907-43746824

Strand

Forward strand

Band

p11.3

Transcripts

ENST00000338702	ENSP00000340684
ENST00000497485
ENST00000490604
ENST00000542639	ENSP00000440846

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008131	primary amine oxidase activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006576	cellular biogenic amine metabolic process
GO:0006805	xenobiotic metabolic process
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0042135	neurotransmitter catabolic process
GO:0042136	neurotransmitter biosynthetic process
GO:0042420	dopamine catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025037

View Gene Order

ENSBTAG00000016206

Not yet available

Pathways

NETPATH

REACTOME

REACT_416

Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB pathway

REACT_15418

Norepinephrine Neurotransmitter Release Cycle pathway

REACT_15511

Enzymatic degradation of Dopamine by monoamine oxidase pathway

REACT_15532

Metabolism of serotonin pathway

REACT_15548

Enzymatic degradation of dopamine by COMT pathway

REACT_15514

Dopamine clearance from the synaptic cleft pathway

REACT_13583

Neurotransmitter Clearance In The Synaptic Cleft pathway

REACT_13685

Neuronal System pathway

REACT_1875

Amine Oxidase reactions pathway

REACT_15391

Serotonin clearance from the synaptic cleft pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_13723

Neurotransmitter Release Cycle pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

REACT_13705

Phase 1 - Functionalization of compounds pathway

KEGG

hsa00340

Histidine metabolism pathway

hsa00360

Phenylalanine metabolism pathway

hsa00330

Arginine and proline metabolism pathway

hsa00260

Glycine, serine and threonine metabolism pathway

hsa00380

Tryptophan metabolism pathway

hsa00350

Tyrosine metabolism pathway

hsa00982

Drug metabolism pathway

INOH

INOH website

Tryptophan degradation pathway

INOH website

Phenylalanine degradation pathway

INOH website

Arginine Proline metabolism pathway

INOH website

Tyrosine metabolism pathway

INOH website

Glycine Serine metabolism pathway

INOH website

Histidine degradation pathway

PID NCI

Cross-References

SwissProt

P21397

TrEMBL

Q5ULA3

UniProt Splice Variant

Entrez Gene

4128

UniGene

Hs.183109 Hs.653990

RefSeq

NM_001270458 NM_000240

HUGO

HGNC:6833

OMIM

309850

CCDS

CCDS59163 CCDS14260

HPRD

02400

IMGT

EMBL

AK293926 AL109855 AY684858 BC008064 BX530072 BX537147 BX537148 M68840 M68843 M68844 M68845 M68846 M68847 M68848 M68849 M68850 M68851 M68852 M68853 M68854 M68855 M68856 M68857 M69226 M89636 S72704 S81371 X60806 X60807 X60808 X60809 X60810 X60811 X60812 X60813 X60814 X60815 X60816 X60817 X60818 X60819

GenPept

AAA59547 AAA59548 AAA59549 AAB46385 AAD14113 AAD14361 AAH08064 AAV34711 BAG57307

RNA Seq Atlas

4128