Homo sapiens Gene: MAOA

Summary
InnateDB Gene IDBG-58306.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol MAOA
Gene Name monoamine oxidase A
Synonyms MAO-A
Species Homo sapiens
Ensembl Gene ENSG00000189221
Encoded Proteins
IDBP-58308 monoamine oxidase A
IDBP-587498 monoamine oxidase A
Entrez Gene
Summary This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X: 43515467-43606068
Strand Forward strand
Band p11.3
Transcripts
ENST00000338702  ENSP00000340684
ENST00000497485 
ENST00000490604 
ENST00000542639  ENSP00000440846
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein‑Protein  3
[view]
Protein‑DNA 1
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 1 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0008131 primary amine oxidase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0051378 serotonin binding
Biological Process
GO:0006576 cellular biogenic amine metabolic process
GO:0006805 xenobiotic metabolic process
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007610 behavior
GO:0042135 neurotransmitter catabolic process
GO:0042136 neurotransmitter biosynthetic process
GO:0042420 dopamine catabolic process
GO:0042428 serotonin metabolic process
GO:0042443 phenylethylamine metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral to membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000025037 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000016206 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
REACT_15511 Enzymatic degradation of Dopamine by monoamine oxidase
REACT_15548 Enzymatic degradation of dopamine by COMT
REACT_15532 Metabolism of serotonin
REACT_416 Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2
REACT_15418 Norepinephrine Neurotransmitter Release Cycle
KEGG
hsa00330  Arginine and proline metabolism
hsa00982  Drug metabolism - cytochrome P450
hsa00260  Glycine, serine and threonine metabolism
hsa00340  Histidine metabolism
hsa01100  Metabolic pathways
hsa00360  Phenylalanine metabolism
hsa00380  Tryptophan metabolism
hsa00350  Tyrosine metabolism
INOH
INOH website Arginine and Proline metabolism
INOH website Glycine and Serine metabolism
INOH website Histidine degradation
INOH website Phenylalanine degradation
INOH website Tryptophan degradation
INOH website Tyrosine metabolism
PID BIOCARTA
PID NCI
Dopamine_clearance_from_the_synaptic_cleft Dopamine clearance from the synaptic cleft
Enzymatic_degradation_of_Dopamine_by_monoamine_oxidase Enzymatic degradation of Dopamine by monoamine oxidase
Enzymatic_degradation_of_dopamine_by_COMT Enzymatic degradation of dopamine by COMT
Metabolism_of_serotonin Metabolism of serotonin
Monoamines_are_oxidized_to_aldehydes_by_MAOA_and_MAOB__producing_NH3_and_H2O2 Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2
Norepinephrine_Neurotransmitter_Release_Cycle Norepinephrine Neurotransmitter Release Cycle
Cross-References
SwissProt P21397 
TrEMBL B4DF46 Q53YE7 Q5UL91 Q5UL94 Q5ULA3 Q5ULA9
UniProt Splice Variant
Entrez Gene 4128 
UniGene Hs.183109 Hs.653990
RefSeq NM_000240  NM_001270458 
HUGO 6833 
OMIM 309850
CCDS CCDS14260 
HPRD 02400
IMGT
EMBL AK291769 AK293926 AL109855 AY684850 AY684858 AY685682 AY685685 BC008064 BT006651 BX530072 BX537147 BX537148 CH471141 M68840 M68843 M68844 M68845 M68846 M68847 M68848 M68849 M68850 M68851 M68852 M68853 M68854 M68855 M68856 M68857 M69226 M89636 S72704 S81371 X60806 X60807 X60808 X60809 X60810 X60811 X60812 X60813 X60814 X60815 X60816 X60817 X60818 X60819
GenPept AAA59547  AAA59548  AAA59549  AAB46385  AAD14113  AAD14361  AAH08064  AAP35297  AAV34705  AAV34711  AAV34717  AAV34720  BAF84458  BAG57307  CAI42421  CAI42424  EAW59381  EAW59383 
ImmGen MAOA (murine) 
RNA Seq Atlas 4128