Version 5.4
Homo sapiens Gene: PTGIR
Summary
InnateDB Gene IDBG-58871.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGIR
Gene Name prostaglandin I2 (prostacyclin) receptor (IP)
Synonyms IP; PRIPR
Species Homo sapiens
Ensembl Gene ENSG00000160013
Encoded Proteins
IDBP-58873
prostaglandin I2 (prostacyclin) receptor (IP)
IDBP-765405
IDBP-763035
IDBP-763879
IDBP-762130
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:46620468-46625118
Strand Reverse strand
Band q13.32
Transcripts
ENST00000291294 ENSP00000291294
ENST00000597185 ENSP00000470566
ENST00000594275 ENSP00000469408
ENST00000595460
ENST00000596260 ENSP00000468970
ENST00000598865 ENSP00000470799
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007596 blood coagulation
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0032496 response to lipopolysaccharide
GO:0043547 positive regulation of GTPase activity
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0048662 negative regulation of smooth muscle cell proliferation
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000043017
View Gene Order
ENSBTAG00000014585
Not yet available
Pathways
NETPATH
REACTOME
REACT_23946
Prostacyclin signalling through prostacyclin receptor pathway
REACT_23876
Platelet homeostasis pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_18425
Prostanoid ligand receptors pathway
REACT_18352
Eicosanoid ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
REACT_604
Hemostasis pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.458324 Hs.689634
RefSeq NM_000960 XM_005259095
HUGO
OMIM
CCDS CCDS12686
HPRD 08959
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca