Version 5.4
Homo sapiens Gene: XRN2
Summary
InnateDB Gene IDBG-58892.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XRN2
Gene Name 5'-3' exoribonuclease 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000088930
Encoded Proteins
IDBP-58894
5'-3' exoribonuclease 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:21303304-21389827
Strand Forward strand
Band p11.22
Transcripts
ENST00000377191 ENSP00000366396
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
Experimentally validated
Total 71 [view]
Protein-Protein 70 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0004534 5'-3' exoribonuclease activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008409 5'-3' exonuclease activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000738 DNA catabolic process, exonucleolytic
GO:0006139 nucleobase-containing compound metabolic process
GO:0006353 DNA-dependent transcription, termination
GO:0006355 regulation of transcription, DNA-templated
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0006401 RNA catabolic process
GO:0007283 spermatogenesis
GO:0016049 cell growth
GO:0016070 RNA metabolic process
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016020 membrane
GO:0016235 aggresome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027433
View Gene Order
ENSBTAG00000011304
Not yet available
Pathways
NETPATH
REACTOME
REACT_16907
Association of TriC/CCT with target proteins during biosynthesis pathway
REACT_16952
Protein folding pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt Q9H0D6
TrEMBL B4DZC3
UniProt Splice Variant
Entrez Gene 22803
UniGene Hs.255932 Hs.644644
RefSeq NM_012255
HUGO HGNC:12836
OMIM 608851
CCDS CCDS13144
HPRD
IMGT
EMBL AF064257 AF152169 AK000084 AK302846 AL117332 AL136841 AL158013 AY382900 BC006417
GenPept AAD55138 AAH06417 AAQ13577 AAR24369 BAA90934 BAG64035 CAB66775 CAH71495 CAI19756
RNA Seq Atlas 22803

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca