Version 5.4
Homo sapiens Gene: POLR1A
Summary
InnateDB Gene IDBG-59571.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR1A
Gene Name polymerase (RNA) I polypeptide A, 194kDa
Synonyms A190; RPA1; RPA194; RPO1-4; RPO14
Species Homo sapiens
Ensembl Gene ENSG00000068654
Encoded Proteins
IDBP-59573
polymerase (RNA) I polypeptide A, 194kDa
IDBP-295359
polymerase (RNA) I polypeptide A, 194kDa
IDBP-295357
polymerase (RNA) I polypeptide A, 194kDa
IDBP-381863
polymerase (RNA) I polypeptide A, 194kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:86020216-86106155
Strand Reverse strand
Band p11.2
Transcripts
ENST00000263857 ENSP00000263857
ENST00000409681 ENSP00000386300
ENST00000409024 ENSP00000386423
ENST00000424089 ENSP00000397321
ENST00000471427
ENST00000496892
ENST00000492034
ENST00000462078
ENST00000483538
ENST00000486964
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 41 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006362 transcription elongation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0010467 gene expression
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005736 DNA-directed RNA polymerase I complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049553
View Gene Order
ENSBTAG00000006481
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_1074
RNA Polymerase I Transcription Termination pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_1913
RNA Polymerase I Promoter Escape pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
hsa03020
RNA polymerase pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F2Z3I7
UniProt Splice Variant
Entrez Gene 25885
UniGene Hs.531818 Hs.594051 Hs.644588 Hs.696718
RefSeq NM_015425 XM_006711983
HUGO HGNC:17264
OMIM
CCDS CCDS42706
HPRD 10161
IMGT
EMBL AC009309 AC012511
GenPept
RNA Seq Atlas 25885

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca