Version 5.4
Homo sapiens Gene: SEPW1
Summary
InnateDB Gene IDBG-59810.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPW1
Gene Name selenoprotein W, 1
Synonyms selW
Species Homo sapiens
Ensembl Gene ENSG00000178980
Encoded Proteins
IDBP-481832
selenoprotein W, 1
IDBP-765159
IDBP-765005
IDBP-766253
IDBP-765576
IDBP-811687
selenoprotein W, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34. [provided by RefSeq, Jul 2008]
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3\' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:47778572-47784686
Strand Forward strand
Band q13.33
Transcripts
ENST00000509570 ENSP00000422644
ENST00000599590
ENST00000601937
ENST00000599874 ENSP00000470135
ENST00000601048 ENSP00000473185
ENST00000599627
ENST00000601419
ENST00000602163
ENST00000598956
ENST00000593892 ENSP00000471149
ENST00000595509
ENST00000598273
ENST00000599302
ENST00000598083
ENST00000595615 ENSP00000470941
ENST00000612212 ENSP00000480640
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008430 selenium binding
GO:0016209 antioxidant activity
Biological Process
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041571
View Gene Order
ENSBTAG00000008203
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.603350
RefSeq NM_003009
HUGO
OMIM
CCDS CCDS59402
HPRD 08377
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca