InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CLCF1

Summary

InnateDB Gene

IDBG-60145.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLCF1

Gene Name

cardiotrophin-like cytokine factor 1

Synonyms

BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6

Species

Homo sapiens

Ensembl Gene

ENSG00000175505

Encoded Proteins

IDBP-60147

cardiotrophin-like cytokine factor 1

IDBP-591904

cardiotrophin-like cytokine factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:67364168-67374177

Strand

Reverse strand

Band

q13.2

Transcripts

ENST00000312438	ENSP00000309338
ENST00000533438	ENSP00000434122

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005127	ciliary neurotrophic factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002639	positive regulation of immunoglobulin production
GO:0007166	cell surface receptor signaling pathway
GO:0007259	JAK-STAT cascade
GO:0008284	positive regulation of cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0030183	B cell differentiation
GO:0030890	positive regulation of B cell proliferation
GO:0040007	growth
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043524	negative regulation of neuron apoptotic process
GO:0048295	positive regulation of isotype switching to IgE isotypes
GO:0048711	positive regulation of astrocyte differentiation

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0097058	CRLF-CLCF1 complex
GO:0097059	CNTFR-CLCF1 complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040663

View Gene Order

ENSBTAG00000046110

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

Q9UBD9

TrEMBL

UniProt Splice Variant

Entrez Gene

23529

UniGene

Hs.502977

RefSeq

NM_001166212 NM_013246

HUGO

HGNC:17412

OMIM

607672

CCDS

CCDS31617 CCDS53666

HPRD

IMGT

EMBL

AF172854 AF176911 AF176912 AK298052 AP003419 AY049779 BC012939 BC066229 BC066230 BC066231 CH471076

GenPept

AAD54284 AAF00991 AAF00992 AAH12939 AAH66229 AAH66230 AAH66231 AAL15436 BAG60346 EAW74601

RNA Seq Atlas

23529