Version 5.4
Homo sapiens Gene: SIGMAR1
Summary
InnateDB Gene IDBG-60346.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIGMAR1
Gene Name sigma non-opioid intracellular receptor 1
Synonyms ALS16; hSigmaR1; OPRS1; SIG-1R; sigma1R; SR-BP; SR-BP1; SRBP
Species Homo sapiens
Ensembl Gene ENSG00000147955
Encoded Proteins
IDBP-60348
sigma non-opioid intracellular receptor 1
IDBP-587606
sigma non-opioid intracellular receptor 1
IDBP-60356
sigma non-opioid intracellular receptor 1
IDBP-477424
sigma non-opioid intracellular receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2008]
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:34634722-34637809
Strand Reverse strand
Band p13.3
Transcripts
ENST00000277010 ENSP00000277010
ENST00000353468 ENSP00000434453
ENST00000378892 ENSP00000368170
ENST00000477726 ENSP00000420022
ENST00000461426
ENST00000497006
ENST00000478146
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004985 opioid receptor activity
GO:0005515 protein binding
GO:0008144 drug binding
Biological Process
GO:0006869 lipid transport
GO:0007399 nervous system development
GO:0008219 cell death
GO:0038003 opioid receptor signaling pathway
GO:0043523 regulation of neuron apoptotic process
Cellular Component
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005640 nuclear outer membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid particle
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030426 growth cone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036078
View Gene Order
ENSBTAG00000015804
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.522087
RefSeq NM_001282205 NM_001282206 NM_001282207 NM_001282208 NM_005866 NM_147157
HUGO
OMIM
CCDS CCDS6562 CCDS6563
HPRD 03580
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca