Version 5.4
Homo sapiens Gene: ACADS
Summary
InnateDB Gene IDBG-60995.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACADS
Gene Name acyl-CoA dehydrogenase, C-2 to C-3 short chain
Synonyms ACAD3; SCAD
Species Homo sapiens
Ensembl Gene ENSG00000122971
Encoded Proteins
IDBP-60997
acyl-CoA dehydrogenase, C-2 to C-3 short chain
IDBP-384236
acyl-CoA dehydrogenase, C-2 to C-3 short chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with Short Chain Acyl-CoA Dehydrogenase Deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:120725735-120740008
Strand Forward strand
Band q24.31
Transcripts
ENST00000242592 ENSP00000242592
ENST00000411593 ENSP00000401045
ENST00000539690
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0003995 acyl-CoA dehydrogenase activity
GO:0004085 butyryl-CoA dehydrogenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042594 response to starvation
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046359 butyrate catabolic process
GO:0051289 protein homotetramerization
GO:0051384 response to glucocorticoid
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0031966 mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029545
View Gene Order
ENSBTAG00000007484
Not yet available
Pathways
NETPATH
REACTOME
REACT_1887
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
REACT_419
Beta oxidation of butanoyl-CoA to acetyl-CoA pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1473
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_1541
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
REACT_111217
Metabolism pathway
KEGG
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00650
Butanoate metabolism pathway
hsa00071
Fatty acid degradation pathway
INOH
INOH website
Butanoate metabolism pathway
INOH website
Valine Leucine Isoleucine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.507076
RefSeq NM_000017
HUGO
OMIM
CCDS CCDS9207
HPRD 06053
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca