Version 5.4
Homo sapiens Gene: P2RX4
Summary
InnateDB Gene IDBG-61373.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2RX4
Gene Name purinergic receptor P2X, ligand-gated ion channel, 4
Synonyms P2X4; P2X4R
Species Homo sapiens
Ensembl Gene ENSG00000135124
Encoded Proteins
IDBP-61375
purinergic receptor P2X, ligand-gated ion channel, 4
IDBP-61377
purinergic receptor P2X, ligand-gated ion channel, 4
IDBP-592943
purinergic receptor P2X, ligand-gated ion channel, 4
IDBP-590082
purinergic receptor P2X, ligand-gated ion channel, 4
IDBP-589633
purinergic receptor P2X, ligand-gated ion channel, 4
IDBP-599802
purinergic receptor P2X, ligand-gated ion channel, 4
IDBP-595817
purinergic receptor P2X, ligand-gated ion channel, 4
IDBP-588969
purinergic receptor P2X, ligand-gated ion channel, 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:121209857-121234106
Strand Forward strand
Band q24.31
Transcripts
ENST00000314442
ENST00000337233 ENSP00000336607
ENST00000359949 ENSP00000353032
ENST00000397924
ENST00000499638
ENST00000543430
ENST00000540930
ENST00000543318 ENSP00000444274
ENST00000543984 ENSP00000439386
ENST00000538701 ENSP00000444033
ENST00000542067 ENSP00000438329
ENST00000541187
ENST00000538417 ENSP00000437396
ENST00000543171 ENSP00000438131
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005102 receptor binding
GO:0005216 ion channel activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0042803 protein homodimerization activity
GO:0045296 cadherin binding
Biological Process
GO:0001894 tissue homeostasis
GO:0002028 regulation of sodium ion transport
GO:0006809 nitric oxide biosynthetic process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0007165 signal transduction
GO:0008217 regulation of blood pressure
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0019228 neuronal action potential
GO:0019233 sensory perception of pain
GO:0032308 positive regulation of prostaglandin secretion
GO:0033198 response to ATP
GO:0034220 ion transmembrane transport
GO:0034405 response to fluid shear stress
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042118 endothelial cell activation
GO:0042311 vasodilation
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0050850 positive regulation of calcium-mediated signaling
GO:0051260 protein homooligomerization
GO:0051899 membrane depolarization
GO:0051928 positive regulation of calcium ion transport
GO:0055117 regulation of cardiac muscle contraction
GO:0055119 relaxation of cardiac muscle
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0071318 cellular response to ATP
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005639 integral component of nuclear inner membrane
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0045177 apical part of cell
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029470
View Gene Order
ENSBTAG00000010812
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.321709
RefSeq NM_001256796 NM_001261397 NM_001261398 NM_002560
HUGO
OMIM
CCDS CCDS58282 CCDS9214
HPRD 09017
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca