Version 5.4
Homo sapiens Gene: IGHMBP2
Summary
InnateDB Gene IDBG-61678.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGHMBP2
Gene Name immunoglobulin mu binding protein 2
Synonyms CATF1; HCSA; HMN6; SMARD1; SMUBP2; ZFAND7
Species Homo sapiens
Ensembl Gene ENSG00000132740
Encoded Proteins
IDBP-61680
immunoglobulin mu binding protein 2
IDBP-602093
immunoglobulin mu binding protein 2
IDBP-595636
immunoglobulin mu binding protein 2
IDBP-718979
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a helicase superfamily member that binds a specific DNA sequence from the immunoglobulin mu chain switch region. Mutations in this gene lead to spinal muscle atrophy with respiratory distress type 1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:68903842-68940602
Strand Forward strand
Band q13.3
Transcripts
ENST00000255078 ENSP00000255078
ENST00000544541 ENSP00000443343
ENST00000539224 ENSP00000440465
ENST00000545146 ENSP00000456366
ENST00000536803
ENST00000539064
ENST00000537458
ENST00000543739
ENST00000541229
ENST00000545475
ENST00000544521
ENST00000568742
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
GO:0008134 transcription factor binding
GO:0008186 RNA-dependent ATPase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0032575 ATP-dependent 5'-3' RNA helicase activity
GO:0043022 ribosome binding
GO:0043141 ATP-dependent 5'-3' DNA helicase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006412 translation
GO:0008219 cell death
GO:0032508 DNA duplex unwinding
GO:0051260 protein homooligomerization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030424 axon
GO:0030426 growth cone
GO:0030529 ribonucleoprotein complex
GO:0032797 SMN complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024831
View Gene Order
ENSBTAG00000022185
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.604969
RefSeq NM_002180 XM_005273974
HUGO
OMIM
CCDS CCDS8187
HPRD 02736
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca