InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CA4

Summary

InnateDB Gene

IDBG-62161.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CA4

Gene Name

carbonic anhydrase IV

Synonyms

CAIV; Car4; RP17

Species

Homo sapiens

Ensembl Gene

ENSG00000167434

Encoded Proteins

IDBP-62163

carbonic anhydrase IV

IDBP-761439

IDBP-761744

IDBP-758857

IDBP-764874

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:60149936-60170899

Strand

Forward strand

Band

q23.1

Transcripts

ENST00000300900	ENSP00000300900
ENST00000591725	ENSP00000466964
ENST00000587265	ENSP00000464757
ENST00000590203	ENSP00000465837
ENST00000586876	ENSP00000467465
ENST00000585705

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004089	carbonate dehydratase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006730	one-carbon metabolic process
GO:0008152	metabolic process
GO:0015701	bicarbonate transport
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0048513	organ development
GO:0048545	response to steroid hormone

Cellular Component

GO:0005791	rough endoplasmic reticulum
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0016529	sarcoplasmic reticulum
GO:0030658	transport vesicle membrane
GO:0030667	secretory granule membrane
GO:0031225	anchored component of membrane
GO:0031362	anchored component of external side of plasma membrane
GO:0031526	brush border membrane
GO:0042383	sarcolemma
GO:0046658	anchored component of plasma membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000000805

View Gene Order

ENSBTAG00000017969

Not yet available

Pathways

NETPATH

REACTOME

REACT_121123

Reversible hydration of carbon dioxide pathway

REACT_121380

Erythrocytes take up oxygen and release carbon dioxide pathway

REACT_121329

Erythrocytes take up carbon dioxide and release oxygen pathway

REACT_120969

O2/CO2 exchange in erythrocytes pathway

REACT_111217

Metabolism pathway

KEGG

hsa00910

Nitrogen metabolism pathway

hsa04964

Proximal tubule bicarbonate reclamation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

B4DQA4

UniProt Splice Variant

Entrez Gene

762

UniGene

Hs.89485

RefSeq

NM_000717 XM_005257639

HUGO

HGNC:1375

OMIM

114760

CCDS

CCDS11624

HPRD

00261

IMGT

EMBL

AC025048 AK298710

GenPept

BAG60866

RNA Seq Atlas

762